Inflammation is a part of the body’s response to harmful stimuli, such as damaged cells, irritants, and pathogens. It is characterized by vasodilation, accumulation of fluid, and the extravasation of immune cells (primarily leukocytes). Magnetic nanoparticles can be loaded into a variety of cells (monocytes and other leukocytes) and those cells tracked as they home in to the region giving off the inflammatory signals. Or, the nanoparticles can be injected directly into the animal, where they are up-taken by phagocytotic cells, which also home in to the inflammation. This inflammation can be tracked for days or even weeks, and one can quantitate the amount of iron that accumulates in the inflammatory region. A range of models can be addressed, from physical injury, stroke, tumor growth, etc.

References:

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  2. Meola et al. Magnetic Particle Imaging (MPI) in Neurosurgery. World Neurosurgery. (2019)
  3. Wu et al. A Review of Magnetic Particle Imaging and Perspectives on Neuroimaging. Am Soc Neuro. (2019)