Magnetic Particle Imaging of the vasculature to assess blood delivery and tissue level perfusion. The direct quantitation of nanoparticle tracers enables accurate perfusion measurements without confounding background tissue signal. Long circulating tracers persist within the vasculature for days, enabling repeated measurements for longitudinal studies. This enables truly functional imaging to measure changes in blood flow and tracer delivery over time in stroke and tumor models. 

Vasculature in a rat head

References:

  1. Yu et al. Magnetic particle imaging: A novel in vivo imaging platform for cancer detection. Nano Letters. (2017)
  2. Wu et al. A Review of Magnetic Particle Imaging and Perspectives on Neuroimaging. American Journal of Neuroradiology. (2019)
  3. Yu et al. Magnetic particle imaging for Highly Sensitive, Quantitative and Safe in vivo Gut Bleed Detection in a Murine Model. ACS Nano. (2017)